Product Description

Exenatide Synthesis and Impurities

Exenatide is mainly synthesized by the classic solid-phase synthesis method combined with fragment synthesis method. During the synthesis, placement and preparation process of exenatide, some miscellaneous peptides similar in structure and properties to exenatide will be produced, such as Amino acid insertion/deletion, diastereoisomers, etc., the structure and physicochemical properties of these exenatide impurities are almost the same as exenatide. The analysis of these exenatide impurities will help us better understand its medicinal chemical properties and provide more support for the research and development of exenatide.

Peptide Characterization and Exenatide Impurities

The identification of peptides is not simple and can be completed by a single detection. The confirmation of its primary structure generally uses mass spectrometry to determine the relative molecular mass, chromatography to determine the amino acid composition, and mass spectrometry combined with enzyme digestion or Edman degradation to determine the peptide sequence. The secondary structure of a polypeptide is actually a local structure formed by the peptide chain due to hydrogen bonds. Its confirmation generally includes detection methods such as X-ray single crystal diffraction, nuclear magnetic resonance, infrared, ultraviolet, and circular dichroism.

High-performance liquid chromatography (HPLC) is the main method for the identification, separation and quantification of peptides and their related impurities. The development of long-acting formulations of Exenatide includes PEG derivatives and dimerized Exenatide, microsphere injections, etc.

Omizzur Biotech 

Omizzur Biotech is a custom peptide synthesis company in China. Omizzur provides a series of customized synthesis services for exenatide impurities, Salmon Calcitonin, Octreotide, Tripeptide, etc with analysis reports ,certificates for HPLC, MS, COA, COO,BSE, etc. Omizzur sign a customer privacy agreement to 100% protect customer privacy . Please send inquiry to Omizzur team for help.